热作用致人前列腺增生组织的光穿透深度变化

魏华江; 邢达; 何博华; 吴荣海; 谷怀民; 巫国勇; 陈雪梅

热作用致人前列腺增生组织的光穿透深度变化

1.
华南师范大学激光生命科学研究所激光生命科学教育部重点实验室, 广州 510631;
2.
广东药学院临床医学系, 外科广州 510224;
3.
广东省江门市中心医院泌尿外科, 江门 529071;
4.
中山大学第一附属医院, 眼科广州 510080

作者简介: 魏华江(1961- ),男,副教授,研究方向为激光医学及组织光学.E-mail:weihj@scnu.edu.cn.

通讯作者: 魏华江, weih@jscnu.edu.cn ;

基金项目:
国家自然科学基金面上资助项目(6037804330470494);广东省自然科学基金资助项目(01501204010394);广东省科技计划资助项目(2004B10401011)
中图分类号: Q631;R318.51

Thermal change on optical penetration depth in human prostatic hyperplasia tissue in vitro

1.
MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China;
2.
Department of Surgery, Department of Clinical Medicine, Guangdong College of Pharmacy, Guangzhou 510224, China;
3.
Department of Urology, Central Hospital of Jiangmen, Jiangmen 529071, China;
4.
Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;

Corresponding author: WEI Hua-jiang, weih@jscnu.edu.cn ;

CLC number: Q631;R318.51

摘要: 为了研究热作用下人良性前列腺增生(BPH)组织对532nm,670nm,830nm和1064nm的光穿透深度的变化及其差异。采用了双积分球测量系统以及反向倍增法获取组织的光学特性。得到的实验结果为:在20℃~80℃的温度范围内,BPH组织对532nm,670nm,830nm和1064nm的光穿透深度都是随着激光波长的增大而增大,随着热作用温度的变化而改变的。随着热作用温度的升高,BPH组织对1064nm的光穿透深度的变化显著地较其对532nm,670nm,830nm的光穿透深度的变化都要大得多。其对532nm,670nm,830nm和1064nm的光穿透深度的最大值分别在50℃,50℃,50℃和70℃,其值分别为0.404mm,0.539mm,0.699mm和5.917mm;最小值分别在20℃,20℃,80℃和60℃,其值分别为0.251mm,0.449mm,0.621mm和1.542mm。该测量结果可为激光的光热治疗BPH提供一点有益的参考。
- 医用光学与生物技术 /
- 组织光学 /
- 积分球 /
- 人良性前列腺增生组织 /
- 激光 /
- 光穿透深度
Abstract: Thermal change and its difference on the optical penetration depth of human benign prostatic hyperplasia(BPH) tissue was measured with a double-integrating-sphere setup at 532nm,670nm,830nm and 1064nm. The optical properties of BPH tissue were assessed from the measurement results using the inverse adding-doubling method.The results of measurement showed that,in exposure temperature range from 20℃ to 80℃,the optical penetration depth of BPH tissue at 532nm,670nm,830nm and 1064nm increased with increase of wavelengths,the optical penetration depth of BPH tissue at 532nm,670nm,830nm and 1064nm varied with a change of exposure temperature by thermal effect,change of the optical penetration depth of BPH tissue at 1064nm was significantly bigger than that of BPH tissues at 532nm,670nm and 830nm,respectively with increase of exposure temperature.Maximal optical penetration depths of BPH tissue at 532nm,670nm,830nm and 1064nm were respectively 0.404mm,0.539mm,0.699mm and 5.917mm at exposure temperature of 50℃,50℃,50℃ and 70℃,respectively,andminimal optical penetration depths were respectively 0.251mm,0.449mm,0.621mm and 1.542mm at exposure temperature of 20℃,20℃,80℃ and 60℃.The results of measurement indicated a few useful reference data for treatment of BPH using optical and thermal properties of laser.

[1]	XU Y M,ZHANG J,JIN C R,et al.Potassium titanyl phosphate laser vaporization prostatectomy for the treatment of benign prostatic hyperplasia[J].Chinese Journal of Urology,2004,25 (9):631-633 (in Chinese).
[2]	FANG J,XU G,DING Q,et al.Observation on the safety and efficacy of He-Ne laser equipment on chronic abacteria prostatitis[J].Journal of Fudan University (Medical Sciences),2005,32(2):234-235 (in Chinese).
[3]	QIN W J,WANG H,WANG F L,et al.Diode laser in treating prostatic hyperplasia:review of 420 cases[J].Journal of Fourth Military Medical University,2004,25 (18):1686-1688(in Chinese).
[4]	HONG B F,CHEN Y F,FU W J,et al.Experience with sacral block regional anesthesia for green light photoselectivc vaporization of prostate[J].Academic Journal of PLA Postgraduate Medical School,2006,27(1):58-59(in Chinese).
[5]	CHEN J B,XU X P,OU M R,et al.Effect of photodynamic therapy using HMME on benign prostatic hyperplasia in rats:a preliminary experimental investigation[J].Journal of Fuzhou University (Natural Science),2005,33 (4):545-548 (in Chinese).
[6]	ZHU D,LUO Q M,ZENG S Q,et al.Change in the optical properties of slowly heated human whole blood and albumen[J].Acts Optica Sinica,2002,22 (3):369-373 (in Chinese).
[7]	ESENALIEV R,LARINA I,LARIN K,et al.Laser optoaconstic technique for real-time measurement of thermal damage in tissues[J].SHE,1999,3594:98-109.
[8]	CHAN E,MENOVSKY T,WELCH A J.Effects of cryogenic grinding on soft-tissue optical properties[J].Appl Opt,1996,35 (22):4526-4532.
[9]	WEI H J,XING D,WU G Y,et al.Differences in optical properties between healthy and pathological human colon tissues using a Ti:sapphire laser:an in vitro study using the Monte Carlo inversion technique[J].Journal of Biomedical Optics,2005,10 (4):044022-1-044022-8.
[10]	ZHU D,LUO Q M,ZHU G M,et al.Kinetic thermal response and damage in laser coagulation of tissue[J].Lasers in Surgery and Medicine,2002,31(5):313-321.
[11]	WEI H J,LI X Y,LIU X X,et al.Scattering and absorbing characteristics of rabbit arteries and veins in Kubelka-Mnnk model at 488.0nm wavelength of Ar+ laser in vitro[J].Laser Technology,2001,25(6):460-463(in Chinese).
[12]	WEI H J,HE B H,CHEN X M,et al.Pathological changes and thermal coagulation of human liver tissue induced changes in the optical penetration depths in vitro[J].Laser Technology,2007,31(1):31-34(in Chinese).
[13]	WEI H J,LI X Y,WU G Y,et al.Transmittance absorption coefficients and scattering phase functions of human artery and vein for He-Ne laser[J].Laser Technology,2000,24 (6):345-348 (in Chinese).
[14]	WEI H J,XING D,LU J J,et al.Total attenuation coefficients of human bladder at different lasers measured by using the direct and indirect methods in vitro[J].Laser Technology,2005,29 (4):420-422(in Chinese).
[15]	PICKERING J W,MOES C J M,STERENBORG H J C M,et al.Two integrating spheres with an intervening scattering sample[J].J O S A,1992,9(4):621-631.
[16]	PRAHL S A,van GEMERT M J C,WELCH A J.Determining the optical properties of turbid media by using the adding-doubling method[J].Appl Opt,1993,32(4):559-568.
[17]	BOLIN F P,PREUSS L E,TAYLOR R C,et al.Refractive index of some mammalian tissues using a fiber optic cladding method[J].Appl Opt,1989,28(12):2297-2303.

[1]	余小敏 . 激光技术在良性前列腺增生手术的应用及发展. 激光技术, 2011, 35(5): 718-720. doi: 10.3969/j.issn.1001-3806.2011.05.038
[2]	来建成 , 李振华 , 王春勇 , 王清华 , 贺安之 . 肌肉组织的光透射特性与辐射传输理论的修正. 激光技术, 2007, 31(3): 265-267,280.
[3]	杨丽 , 孙建华 . 生物组织光学特性参量的图像测量研究. 激光技术, 2010, 34(6): 743-746,769. doi: 10.3969/j.issn.1001-3806.2010.06.007
[4]	张连顺 , 张晓晖 , 王章祯 . 由漫射图像测量生物组织的光学特性. 激光技术, 2011, 35(5): 675-677. doi: 10.3969/j.issn.1001-3806.2011.05.027
[5]	孔梅梅 , 高志山 , 陈磊 , 李新华 . 人眼光学模型的研究与发展. 激光技术, 2008, 32(4): 370-373.
[6]	魏华江 , 邢达 , 鲁建军 , 沈行燕 , 巫国勇 . 直接和间接法测量人膀胱对激光的总衰减系数. 激光技术, 2005, 29(4): 420-422.
[7]	周建华 , 刘登瀛 , 徐建中 , 淮秀兰 . 激光加热时冷冻生物组织内解冻过程的数值模拟. 激光技术, 2002, 26(6): 468-470.
[8]	秦建华 , 余重秀 , 谭永红 , 苏密勇 , 王子民 . 光源面分布对激光针灸经穴组织的漫反射影响. 激光技术, 2011, 35(4): 551-553,558. doi: 10.3969/j.issn.1001-3806.2011.04.027
[9]	何军锋 , 谭毅 . 光声成像技术在生物医学中的研究进展. 激光技术, 2007, 31(5): 530-533,536.
[10]	吴剑波 , 骆清铭 . 激光三角法在生物医学领域中的若干应用. 激光技术, 2006, 30(1): 1-4.
[11]	陈金宝 , 张正文 , 赵伊君 . 金属材料对连续波红外激光的热耦合系数. 激光技术, 1997, 21(2): 81-83.
[12]	范晓红 , 李正佳 , 周海 , 何艳艳 . 分布Er：YAG激光对皮肤光致热分解作用数值分析. 激光技术, 2010, 34(2): 181-184. doi: 10.3969/j.issn.1001-3806.2010.02.011
[13]	张鹏 , 牛燕雄 , 王秀生 , 武东生 . 激光劝阻器技术的研究与设计. 激光技术, 2005, 29(4): 392-394.
[14]	刘继常 , 李力钧 , 朱小东 , 陈洪 . 试析几种激光复合焊接技术. 激光技术, 2003, 27(5): 486-489.
[15]	杨在富 , 钱焕文 , 高光煌 . 激光告警技术发展现状. 激光技术, 2004, 28(1): 98-102.
[16]	李玉瑶 , 王菲 , 孙同同 . 薄膜激光损伤阈值标定技术. 激光技术, 2021, 45(6): 729-734. doi: 10.7510/jgjs.issn.1001-3806.2021.06.009
[17]	王挺峰 , 付有余 , 郭劲 , 米阳 . 利用光栅测量远场入射激光波长的方法研究. 激光技术, 2005, 29(2): 156-158.
[18]	陶小红 , 孙晓泉 , 蔡晓春 . 激光干扰星载CCD的技术研究. 激光技术, 2005, 29(4): 414-416.
[19]	赵建军 , 侯彦东 . 基于激光技术的高炮射击训练模拟系统. 激光技术, 2003, 27(6): 567-568,571.
[20]	邓之兵 , 李岩 , 韩艳梅 , 张书练 . 用双折射激光频率分裂原理实现的静态与动态测量方法. 激光技术, 1999, 23(1): 29-33.

点击查看大图

计量

文章访问数: 3514
HTML全文浏览量: 639
PDF下载量: 409
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

热作用致人前列腺增生组织的光穿透深度变化

作者简介: 魏华江(1961- ),男,副教授,研究方向为激光医学及组织光学.E-mail:weihj@scnu.edu.cn.

通讯作者: 魏华江, weih@jscnu.edu.cn ;

Thermal change on optical penetration depth in human prostatic hyperplasia tissue in vitro

Corresponding author: WEI Hua-jiang, weih@jscnu.edu.cn ;

计量

热作用致人前列腺增生组织的光穿透深度变化

通讯作者: 魏华江, weih@jscnu.edu.cn;

作者简介: 魏华江(1961- ),男,副教授,研究方向为激光医学及组织光学.E-mail:weihj@scnu.edu.cn

English Abstract

Thermal change on optical penetration depth in human prostatic hyperplasia tissue in vitro

Corresponding author: WEI Hua-jiang, weih@jscnu.edu.cn

全文HTML

目录

留言板

热作用致人前列腺增生组织的光穿透深度变化

作者简介: 魏华江(1961- ),男,副教授,研究方向为激光医学及组织光学.E-mail:weihj@scnu.edu.cn.

通讯作者: 魏华江, weih@jscnu.edu.cn ;

Thermal change on optical penetration depth in human prostatic hyperplasia tissue in vitro

Corresponding author: WEI Hua-jiang, weih@jscnu.edu.cn ;

计量

出版历程

热作用致人前列腺增生组织的光穿透深度变化

通讯作者: 魏华江, weih@jscnu.edu.cn;

作者简介: 魏华江(1961- ),男,副教授,研究方向为激光医学及组织光学.E-mail:weihj@scnu.edu.cn

English Abstract

Thermal change on optical penetration depth in human prostatic hyperplasia tissue in vitro

Corresponding author: WEI Hua-jiang, weih@jscnu.edu.cn

全文HTML

目录