Abstract: In order to confront time delay integration charge coupled device (TDI-CCD) imaging equipment efficiently, theoretical analysis and experiments about pulse laser interference on TDI-CCD with pulse width of 10ns and wavelength of 1.06m were conducted. Interference phenomena and mechanisms were analyzed. Saturation threshold was measured by digital image processing method. The results show that saturation threshold is 1.3mJ/cm2. Interference will be more effective if pulse repetition frequency is higher.